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Saturday, July 11, 2020 | History

2 edition of Studies on the metabolism of methyl mercury and dimethyl mercury in mice. found in the catalog.

Studies on the metabolism of methyl mercury and dimethyl mercury in mice.

Kurt OМ€stlund

Studies on the metabolism of methyl mercury and dimethyl mercury in mice.

by Kurt OМ€stlund

  • 120 Want to read
  • 10 Currently reading

Published by Munksgaard in Copenhagen .
Written in English

    Subjects:
  • Mercury in the body.

  • Edition Notes

    Bibliography: p. 126-132.

    SeriesActa pharmacologica et toxicologica,, v. 27. Supplementum 1, 1969
    Classifications
    LC ClassificationsQP535.H6 O34
    The Physical Object
    Pagination132 p.
    Number of Pages132
    ID Numbers
    Open LibraryOL5517935M
    LC Control Number73527684

    Mercury is a toxic heavy metal which is widely dispersed in nature. Most human exposure results from fish consumption or dental amalgam. Mercury occurs in several chemical forms, with complex pharmacokinetics. Mercury is capable of inducing a wide range of clinical presentations. Diagnosis of mercury toxicity can be challenging but can be obtained with reasonable by: Trasande L, Landrigan PJ, Schechter C. Public health and economic consequences of methyl mercury toxicity to the developing brain. Environmental Health Perspectives. ;(5) SUMMARY. This study shows that the IQ losses associated with methylmercury toxicity cost the U.S. economy billions of dollars in lost productivity each year.

    The death of a chemistry professor in June was apparently due to a single exposure to dimethylmercury. Dimethylmercury belongs to a class of organic mercury compounds known as alkyl mercuries. It is used primarily in research. It is a colorless liquid described as having a weak, sweet odor. Mercury methylation is the process of forming methylmercury (MeHg). The methylation of mercury can occur abiotically or biotically. Biotically, the primary methylators of mercury are sulfate-reducing and iron-reducing bacteria. Three mechanisms have been proposed for the biotic methylation of mercury by sulfate-reducing bacteria. Mercury methylation can be problematic as methylmercury is toxic.

    Structure and chemistry "Methylmercury" is a shorthand for the hypothetical "methylmercury cation", sometimes written "methylmercury(1+) cation" or "methylmercury(II) cation".This functional group is composed of a methyl group bonded to a chemical formula is C H 3 Hg + (sometimes written as MeHg +).Methylmercury exists as a substituent in many complexes of the type [MeHgL] + (L. Methyl mercury is the principle tissue residue form in eggs, regardless of the mercury compound ingested by a bird. Aquatic organisms accumulate methyl mercury from polluted watersheds, bays, etc. Methyl mercury can accumulate in eggs and animal tissues. Dimethyl mercury .


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Studies on the metabolism of methyl mercury and dimethyl mercury in mice by Kurt OМ€stlund Download PDF EPUB FB2

Acta Pharmacol Toxicol (Copenh). ;27 Suppl Studies on the metabolism of methyl mercury and dimethyl mercury in mice. Ostlund by: Studies on the metabolism of methyl mercury and dimethyl mercury in mice KURT ÖSTLUND Department of Food Hygiene, the Department of Pharmacology and the Department of Clinical Chemistry, Royal Veterinary College, Stockholm, by: An autoradiographic study on the distribution of 63NiCl2 in mice.

Ann Clin Lab Sci. Jan-Feb; 9 (1)– Ostlund K. Studies on the metabolism of methyl mercury and dimethyl mercury in mice. Acta Pharmacol Toxicol (Copenh) ; 27 (Suppl 1):1– Sunderman FW, Jr, Selin CE.

The metabolism of nickel by:   The current study sought to compare, in neonatal mice, the tissue concentrations, disposition and metabolism of thimerosal with that of methyl mercury. ICR mice were given single intramuscular injections of thimerosal or methyl mercury ( mg Hg kg −1) on postnatal day 10 Cited by:   An autoradiographic study on the distribution of 63NiCl2 in mice.

Ann Clin Lab Sci. Jan-Feb; 9 (1)– Ostlund K. Studies on the metabolism of methyl mercury and dimethyl mercury in mice. Acta Pharmacol Toxicol (Copenh) ; 27 (Suppl 1):1– Sunderman FW, Jr, Selin CE. The metabolism of nickel carbonyl.

MeHg uptake and elimination rates were quantitated in the blood, liver, spleen, kidney, gastrocenemius muscle, lens, cerebral cortex, The pharmacodynamics of methyl mercury in the mouse cerebellum, suprascapular fat pad, skin, hair and carcass by gamma scintillation by: 1.

Strain differences in excretion of methylmercury in mice () The effect of mercaptodextran and N-acetylhomocysteine on the excretion of mercury in mice after exposure to methyl mercury chloride.

Acta Pharmacol Toxicol –32 östlund K () Studies on the metabolism of methyl mercury and dimethyl mercury in mice. Acta Pharmacol Cited by: 3.

The distribution of methyl mercury at a cellular level has been examined by a histochemical method (Takeuchi, ; Backstrom, ) and the same method has been used to study the subcellular localization of methyl mercury (Chang and Hartmann, a).Cited by: 1.

Magour S. Studies on the inhibition of brain synaptosomal Na+/K+-ATPase by mercury chloride and methyl mercury chloride. Arch Toxicol Suppl. ; – Malagutti KS, da Silva AP, Braga HC, Mitozo PA, Soares dos Santos AR, Dafre AL, de Bem AF, Farina M.

17[beta]-estradiol decreases methylmercury-induced neurotoxicity in male by: She began a sabbatical at Harvard in the fall of ' The work involved doing some model compound studies involving mercury chemistry with Steve Lippard's group at MIT.

That work led to mercury NMR characterization of the model compounds with the use of dimethylmercury as this element's NMR. Methylmercury Metabolism and Elimination Status (MerMES) in Humans Evaluating the potential for methylmercury (MeHg) toxicity relies on accurately predicting the mercury (Hg) body burden that results with eating fish.

The Hg body burden is directly determined by the slow elimination kinetics of MeHg in the human body (t 1/2 ~ 50days). Author(s): Östlund,Kurt, Title(s): Studies on the metabolism of methyl mercury and dimethyl mercury in mice. Country of Publication: Denmark Publisher: [Copenhagen, Munksgaard, ] Description: p.

illus. Language: English MeSH: Mercury/metabolism*; Mice/metabolism* NLM ID: [Book]. striatum, cerebral cortex, thalamus, and hypothalamus were seen in mice receiving methyl mercury by gavage at doses of or mg/kg/day ( or mg Hg/kg/day) for 60 days (Berthoud et al., ).

Chronic Toxicity Humans The chronic toxicity of methyl mercury is best exemplified by the epidemic poisonings in Iraq, andFile Size: KB. The ability of three mercury compounds to induce aberrations in the meiosis of mouse ova in vitro and in vivo was studied.

Although threshold levels of each were shown in vitro to induce severe effects on the nuclei of ova, no immediate or delayed effect could be demonstrated in is suggested that the mouse ovum is protected from the cellular effects of excess mercury by a barrier of Cited by:   The oral intake of μCi of methyl-mercuric nitrate Hg by three clinically healthy, white, male volunteers aged 37 to 44 years resulted in an accumulation in the liver and the head of the Hg.

The main excretory route was the feces but the urinary excretion increased with time up to 30 days after the intake. The biological half-life was found with whole body measurements to be 70 to 74 Cited by:   Methylmercury is a hazardous substance that is of interest with regard to environmental health, as inorganic mercury circulating in the general environment is dissolved into freshwater and seawater, condensed through the food chain, ingested by Cited by: ENVIRONMENTAL RESEARCH g, () Biliary Excretion of Phenyl- and Methyl Mercury Chlorides and their Enterohepatic Circulation in Rats M.

CIKRT AND M. TICHY Institute of Hygiene and Epidemiology, Prague, Czechoslovakia Received Septem The kinetics of biliary excretion of mercury applied as phenyl mercury () chloride (PMC) or methyl mercury () chloride (MMC) Cited by: A systematic study of the disposition and metabolism of mercury species in mice after exposure to low levels of thimerosal (ethylmercury) Article in Environmental Research C August.

PharmaeoL, 25 ) 12 LI';VAN, A., Cytological reactions induced by inorganic salt solutions, Nature, 22 )13 (')STLUND, K., Studies on the metabolism of methyl mercury and dimethyl nlercury in mice, Acta by: Methyl mercury in fish - A case study on various samples collected from Ganges river at West Bengal Article (PDF Available) in Environmental Monitoring and Assessment (6) June.

The uptake and the tissue distribution of ethylmercuric chloride (EMC) by inhalation and oral administration were studied in adult female rats. The pulmonary uptake of EMC linearly increases with the time of exposure and is proportional to the concentration of EMC vapor.

With the exception of stomach, intestine, and hair, the tissue distribution ofHg from pulmonary uptake is quite similar Cited by: 4. The toxicity of mercury varies according to the form in which it comes. Methyl mercury is particularly dangerous and this will be dealt with in more detail below.

Liquid mercury metal is the least toxic; mercury vapour is more dangerous, while the poisonous nature of mercury .The report noted that in studies of patients transfused with a commercial product of human plasma containing percent Thimerosal, as well as in studies of mice injected with an ethylmercury solution, the increased level of inorganic mercury added to the mercury already existing in the body resulted in a “longer biological half-life of total mercury than that reported for methylmercury injection.